St. Francis is a city in Anoka and Isanti counties, Minnesota, United States. The population was 8,142 at the 2020 census. Minnesota Sta…St. Francis is a city in Anoka and Isanti counties, Minnesota, United States. The population was 8,142 at the 2020 census. Minnesota State Highway 47 serves as a main route in the city. Other routes include Ambassador Boulevard.