Cattle that are vaccinated with the BCG vaccine, which contains a harmless strain of the bovine TB pathogen Mycobacterium bovis, produce a positive PPD test for TB making it impossible to ...

BCG, a century-old vaccine for tuberculosis, is in the news, raising hopes for the COVID-19 pandemic. But existing ecological studies have serious limitations. Randomized trials are urgently needed.

Even the relatively recent BCG Pasteur strain, for example, has been passaged 1,173 times. Selective strain The idea that strain differences are contributing to the variation in vaccine efficacy ...

ImmunityBio has gained US Food and Drug Administration (FDA) authorisation for an expanded access programme to supply an ...

Female C57BL/6 mice were inoculated intraperitoneally (i.p.) with 10 6 colony-forming units (CFU) of the BCG strain harboring an empty plasmid (BCG(e)) one month before i.n. immunization with Ad ...

Unlike the BCG strain, Mtb Δppe25-pe19 has an intact ESX-1 transport system. Consistent with this, the researchers show that immunization with Mtb Δppe25-pe19 induces specific immune responses ...

Howard Hughes Medical Institute investigator William R. Jacobs and colleagues have produced a genetically altered strain of tuberculosis, that elicits a stronger immune response than the current ...

Bacillus Calmette-Guérin (BCG) vaccine—named for its developers—contains inactivated mycobacteria that infect cattle and ...

Restoration of genes lost during the original attenuation of the commonly used BCG tuberculosis vaccine enhances the ability of a recombinant strain to protect against Mycobacterium tuberculosis.