Chemical synthesis and peptide ligation techniques have revolutionised the field of protein engineering by enabling the precise construction of peptides and proteins with tailored modifications. These ...

In a recent review article, a research team outlined recent progress in transition metal-free techniques to achieve coupling. Their combined efforts in these methods could help minimize waste and ...

Triple click chemistry has revolutionized chemical synthesis with its simplicity and efficiency, allowing for the quick and selective assembly of complex molecules. Now, in a recent study, researchers ...

A team of chemists has unveiled a novel method to simplify the synthesis of piperidines, a key structural component in many pharmaceuticals. The study combines biocatalytic carbon-hydrogen oxidation ...

DNA synthesis is vital to several processes in biopharmaceutical innovation, including the development of gene therapies, CRISPR gene editing, antisense oligonucleotides and RNA therapies. The need ...

This module explores the synthesis of amines with a focus on the reductive amination reaction. Numerous examples from the discovery and commercial manufacturing of pharmaceuticals are included. After ...

This article explores limitations of chemical synthesis in high-throughput settings and the technical advantages enzymatic ...

Nowadays, there's lots of buzz about spectacular new medical treatments such as personalised cancer therapy with modified immune cells or antibodies. Such treatments, however, are very complex and ...

A new paper published in Nature Biotechnology this week titled, “Template-independent enzymatic synthesis of RNA oligonucleotides,” provides details of a method for synthesizing single-stranded RNA ...

Scientists have long considered ketones (a fundamental chemical class) and esters (molecules formed when an acid reacts with an alcohol) to be locked treasure chests of possibilities. Ubiquitous as ...

Coupling reactions are among the most transformative tools in organic chemistry, enabling the formation of crucial chemical bonds in pharmaceuticals, agrochemicals, and advanced materials. Since their ...