The dual-function phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is the second most frequently mutated gene in human cancers. PTEN counteracts the functions of many growth factors, the ...
Insulin-like growth factors (IGFs) and their binding proteins (BPs) regulate cell differentiation, proliferation and apoptosis, and may have a role in the aetiology of various cancers. Information on ...
Diabetes. 2006;56(2):285-294. Reduced susceptibility to diet-induced obesity was a major finding of the current study. IGFBP-2 mice fed standard chow also had higher insulin sensitivity and lower ...
Neuroendocrine prostate cancer (NEPC) after androgen deprivation therapy (ADT): Clinical characteristics. Background: IGF-1 has been shown to promote cancer growth by activation of PI3 kinase and ...
Insulin-like growth factor (IGF) is a hormone that greatly influences growth in fetuses and children, but also body maintenance and metabolism in adults. IGF regulates cell proliferation, ...
Circulating tumor cells during and beyond maintenance therapy with SERM or aromatase inhibitors for decision making in long-term survivorship. This is an ASCO Meeting Abstract from the 2014 Breast ...
Women with high levels of insulin-like growth factor 1 (IGF-1) may be at increased risk for breast cancer, according to results of a study that used both epidemiological techniques as well as genetic ...
In the current study, the researchers analyzed levels of IGF-1, IGFBP-1, IGFBP-2, and IGFBP-3 in blood taken from 742 women in the Nurses' Health Study (v) who years later developed type 2 diabetes as ...
Vitamin D and insulin-like growth factor-1 (IGF-1) are involved in a complex interplay that may have implications for growth hormone dosing, researchers found. In a review of the literature, patients ...
Many of the changes in my body when I took part in the clinical trial of an intermittent fasting diet were no surprise. Eating very little for five days each month, I lost weight, and I felt hungry. I ...
Scientists determined the cryo-EM structure of IGF Ternary complex and its assembly and activation mechanism. Insulin-like growth factor (IGF) is a hormone that greatly influences growth in fetuses ...
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