Defective metabolism of levodopa in the brain was associated with a decline in the drug's efficacy over time and the adverse effect of dyskinesia among patients with Parkinson disease. Although highly ...

About one million people in the United States are living with Parkinson’s Disease. Levodopa is the most effective drug available, but the drug can cause side effects, and after several years, the ...

Dopa-decarboxylase inhibitor + dopamine precursor. ≥18yrs: Do not crush or chew. Patients not receiving levodopa: initially one Sinemet CR 50–200 tab twice daily, at intervals of at least 6 hrs.

Significant reduction of levodopa-induced dyskinesia by AV-101 observed in "gold standard" MPTP non-human primate model of Parkinson's disease, while maintaining antiparkinsonian activity of levodopa ...

There is currently (April, 2010) no cure for Parkinson’s disease. Therapy focuses on treating the symptoms that undermine the patient’s quality of life. As people have enormously varying symptoms and ...

A study involving 22 Parkinson's disease (PD) patients has shown that use of the dopaminergic drug levodopa improves sleep quality. When the patients took the drug, the number of times they woke up ...