When formulating mRNA into lipid nanoparticles (LNP), various copy numbers of mRNA are encapsulated, leading to a distribution of mRNA loading levels within the LNPs. It is unclear whether the mRNA ...
To make the technique work in cultured mammalian cells, researchers must deliver small interfering RNAs (siRNAs), which are dsRNAs of 21-25 nucleotides, to the cell. They can use a wide range of ...
New Transfection Systems Tackle Delivery Issues and Off-Target Effects Will RNAi-based therapeutics provide the next class of blockbuster drugs? If pharma’s acquisition spree of companies with ...
A Few Key Considerations Are Essential to Obtain the Best Return from Cell-Based Experiments Because optimal DNA delivery into mammalian cells depends on multiple factors, we recommend optimizing ...
Hinnah Campwala (left) is a Principal Scientist in the Cell Biology Development Group at Sartorius BioAnalytical Instruments (Michigan, USA). With a background in drug discovery and immune cell ...
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