DNA is non-randomly arranged in the nucleus, with silent chromatin domains preferentially associating with inner nuclear membrane proteins and lamins in yeast and larger eukaryotes, respectively.

“What used to be a cell with components, the reality of which was often a matter of dispute and functions as a rule unknown is now a system of great organizational sophistication with units for the ...

Each cell contains well-defined compartments, each of which has a specific function. The nuclear envelope, for example, is a highly regulated membrane barrier that separates the nucleus from the ...

The lamin B receptor (LBR) is a polytopic protein of the inner nuclear membrane. It is synthesized without a cleavable amino-terminal signal sequence and composed of a nucleoplasmic amino-terminal ...

In a recent study published in Nature Cell Biology, a team of researchers discovered that the elevated expression of lamin-associated polypeptide 1 (LAP1), an inner nuclear membrane protein, helps ...