Diagnosis: Anti-Ma2 paraneoplastic encephalitis in association with metastatic testicular cancer; initially misdiagnosed as CNS Whipple's disease. A 39-year-old man with remote traumatic brain ...

It can be triggered by an infection elsewhere in the body (post-infectious autoimmune encephalitis) or a tumor ...

NMDAR antibodies are present in serum and CSF, usually with intrathecal synthesis, and are sometimes only detected in the CSF. The main target epitopes are in the NR1/NR2 heteromers of the NMDAR.

Blood and CSF autoimmune and paraneoplastic encephalitis antibodies were negative (including anti-NMDA, anti-GAD65, anti-Hu, anti-Ma2, anti-Tr, anti-amphiphysin, anti-glycine, anti-MOG, anti-AQP4, and ...