This barricade prevents water from breaking the peptide bonds through a process called hydrolysis. "We provide evidence that that interaction prevents water from attacking the peptide bonds and ...

This generally occurs through protease-mediated hydrolysis of peptide bonds, but can also occur through non-enzymatic methods such as by action of mineral acids and heat. LSD1-CoREST-HDAC1/2 ...

Proteases are enzymes that catalyse hydrolysis of the peptide and isopeptide bonds that join amino acids within proteins (known as proteolysis). Proteases can also remove protein post ...