Altogether, this structure–function analysis of MapZ provides the first molecular characterization of a positive regulatory process of bacterial cell division.

Now the structure of pneumococcal autolysin LytC provides insight into its role in cell wall metabolism and fratricide.

THE association of salmonella osteomyelitis with sickle-cell anemia is well known,1 but that of pneumococcal meningitis with sickle-cell anemia has not been reported. In a recent survey of 305 pati ...

Differences in the genetic code of pneumococcal bacteria have been identified by researcher that may explain why it poses such a risk to children with sickle cell disease and why current vaccines ...

A subset of T cells could be the answer to one of the central unanswered questions in pneumococcal research – why are some individuals more resistant to invasive pneumococcal disease than others?

After PCV7 licensure, pneumococcal infection rates in children aged 5+ with sickle cell disease significantly decreased.

More information: Rong Xu et al, TNFR2+ regulatory T cells protect against bacteremic pneumococcal pneumonia by suppressing IL-17A-producing γδ T cells in the lung, Cell Reports (2023).

However, serum from children with sickle-cell disease revealed a marked deficiency in opsonizing activity (Table 2), whether incubated with autologous leukocytes or with cells from a normal subject.

The study, 'The Role of Host and Microbial Factors in the Pathogenesis of Pneumococcal Bacteraemia Arising from a Single Bacterial Cell Bottleneck', has been published in the academic journal PLOS ...

TNFR2+ regulatory T cells protect against bacteremic pneumococcal pneumonia by suppressing IL-17A-producing γδ T cells in the lung.

(Medical Xpress)—Researchers have identified differences in the genetic code of pneumococcal bacteria that may explain why it poses such a risk to children with sickle cell disease and why ...