The San Francisco 49ers had a productive offense under coach Kyle Shanahan for a while when the team made the big deal to acquire Christian McCaffrey from Carolina three years ago. The addition of one of the NFL's best dual-threat backs ever elevated that offense to another level that will be on display for the Panthers (6-5) when they face the 49ers (7-4) on Monday night for the first time since that trade in

NFL.com's Bobby Kownack breaks down three must-know storylines for Monday's Week 12 game between the Carolina Panthers and San Francisco 49ers at Levi's Stadium.

Since the trade on October 20, 2022, the Carolina Panthers have gone 19-37, the sixth-worst record in the NFL. On the other side, the 49ers have gone 35-21, sixth-best record in the NFL, including 4-2 in the playoffs and a Super Bowl appearance.

Find out why Xavier Legette anchors our all-wide receiver same-game parlay play for MNF. Free Panthers vs. 49ers SGP picks and NFL wagering advice for November 24, 2025.

The NFL season continues in Week 11 when the San Francisco 49ers host the Arizona Cardinals on Sunday. Start time, how to watch, streaming and NFL schedule.

George Kittle is hot, and the run is expected to extend on Monday Night Football against the Carolina Panthers. Thomas Valentine of Pro Football Focus went through the matchup to watch on the game and noted that Kittle may be have a great opportunity.

Everything you need to know on how to watch San Francisco 49ers vs Carolina Panthers NFL Game - team news, livestream, TV channel, and start time.

San Francisco 49ers star tight end George Kittle reflects on the blockbuster trade with the Carolina Panthers to land Christian McCaffrey.

Recent reports have suggested that San Francisco 49ers WR Brandon Aiyuk has played his final game with the franchise.