Although previously thought to be neutral, research in yeast suggests that synonymous point mutations may have strongly nonneutral effects. A group of researchers from the University of Michigan (MI, ...

Several studies involving genome-wide scans of non-synonymous SNPs (nsSNPs) have successfully identified loci contributing to common complex diseases. We were interested in the extent to which these ...

A central assumption about so-called synonymous mutations, which are changes in the coding sequence of proteins that do not lead to changes in its amino acid sequence, is being questioned by a study ...

To their surprise, the researchers found that 75.9% of synonymous mutations were significantly deleterious, while 1.3% were significantly beneficial. “The previous anecdotes of nonneutral synonymous ...

Although synonymous (or “silent”) variants have no effect on amino acid sequence, some synonymous variants influence fitness and susceptibility to disease. Mechanisms include interference with ...