Nature

Major Molecular Events of DNA Replication

Arthur Kornberg compared DNA to a tape recording of instructions that can be copied over and over. How do cells make these near-perfect copies, and does the process ever vary? In reality, the process ...
The New England Journal of Medicine

DNA — Structure and Enzymatic Synthesis (Concluded)

32 P-label is introduced by incoming dGT 32 P molecule. The arrows indicate the sites of enzymatic hydrolysis. The bases of the template DNA strand are designated as clear boxes, and the bases in the ...
JSTOR Daily

Primer release is the rate-limiting event in lagging-strand synthesis mediated by the T7 replisome

Proceedings of the National Academy of Sciences of the United States of America, Vol. 113, No. 21 (May 24, 2016), pp. 5916-5921 (6 pages) DNA replication occurs semidiscontinuously due to the ...
Nature

Lagging-strand replication shapes the mutational landscape of the genome

The origin of mutations is central to understanding evolution and of key relevance to health. Variation occurs non-randomly across the genome, and mechanisms for this remain to be defined. Here we ...
JSTOR Daily

In vitro Synthesis of Infectious Poliovirus RNA

Proceedings of the National Academy of Sciences of the United States of America, Vol. 82, No. 24 (Dec. 15, 1985), pp. 8424-8428 (5 pages) Replication of the infectious RNA genome of poliovirus is ...