More information: Hongxing Shen et al, HIF1α-regulated glycolysis promotes activation-induced cell death and IFN-γ induction in hypoxic T cells, Nature Communications (2024). DOI: 10.1038 ...

INAB READ THE FULL INAB RESEARCH REPORT Following the announcement of its new γδ T cell engager platform INB-600, IN8bio, Inc ...

In myeloma treatment, acute CRS is a common but treatable AE associated with CAR T-cell therapy and bispecific antibodies, ...

A T-cell therapy developed by Orca Bio, a private biotech company, significantly reduced the risk of a debilitating immune ...

T cells are designed to recognise the molecular signatures of particular proteins, such as those from bacteria, in order to activate an immune response. Macrophages eat other cells and are able to ...

A pivotal study 1 in 2011 used second-generation CAR T cells to achieve sustained T cell activation and remission for the majority of patients tested. A year later came another major breakthrough ...

Genome-wide transcriptomics analysis of IFNγ-producing or IL-17A-producing γδ T cell subpopulations reveals marked differences in their mode of activation and functional potential in the periphery.

Researchers at the Francis Crick Institute have shown that water influx is necessary for immune cells called T cells to activate and divide in response to a threat. T cells defend against ...

Investigators found that lipid metabolism disruptions spark T-cell dysfunction in patients with chronic lymphocytic leukemia.

The therapy, a fully human monoclonal antibody, targets a newly identified immune checkpoint protein that could enhance ...