More information: Hongxing Shen et al, HIF1α-regulated glycolysis promotes activation-induced cell death and IFN-γ induction in hypoxic T cells, Nature Communications (2024). DOI: 10.1038 ...

Marengo Therapeutics’ breakthrough discovery in T cell receptor (TCR) activation blazes a new trail for safe treatment and long-term protection against cancer. Immuno-oncology (IO) has ...

INAB READ THE FULL INAB RESEARCH REPORT Following the announcement of its new γδ T cell engager platform INB-600, IN8bio, Inc ...

Our blood consists of many cell types that develop through different stages from a precursor type -- the blood stem cell. An international research team has now investigated the developmental pathways ...

T cells are designed to recognise the molecular signatures of particular proteins, such as those from bacteria, in order to activate an immune response. Macrophages eat other cells and are able to ...

Researchers at the Francis Crick Institute have shown that water influx is necessary for immune cells called T cells to activate and divide in response to a threat. T cells defend against ...

Investigators found that lipid metabolism disruptions spark T-cell dysfunction in patients with chronic lymphocytic leukemia.

As noted above, stellate cell activation is the central event in hepatic fibrosis. Activation consists of 2 major phases: (1) initiation (also called apreinflammatory stage) and (2) perpetuation ...

VDAC2 deficiency elicits uncontrolled IFNγ-induced BAK activation and mitochondrial damage for improved cancer therapy. Pathogenic T helper type 2 cells (pTh2) are involved in allergic asthma ...

Mast cell activation syndrome, a disorder involving immune cells gone awry, is increasingly recognized as the culprit behind many medical mysteries. The first key to understanding this complex ...