Preview the Week 12 matchup between the Indianapolis Colts and Kansas City Chiefs with predictions, odds, over/under, spread, betting lines and more.

Oct 5, 2025; Indianapolis, Indiana, USA; Indianapolis Colts safety Cam Bynum (0) high fives cornerback Charvarius Ward (7) after an interception against the Las Vegas Raiders during the second quarter at Lucas Oil Stadium. / Trevor Ruszkowski-Imagn Images

Patrick Mahomes has never lost three consecutive regular-season starts, and the Chiefs haven't been below .500 through 11 games since 2012, but both of those streaks are at risk Sunday when Kansas City hosts the Indianapolis Colts in a crucial Week 12 showdown.

Colts HC Shane Steichen had good news to share regarding the team's injury report for Sunday's showdown with Chiefs

Kansas City Chiefs TE Travis Kelce spoke out about his future with the organization as he enters the final year of his contract.

The dads, Brads and Chads might need to reverse course if they want any hope of the Kansas City Chiefs making the playoffs. It’s been a rollercoaster of a season for the Chiefs thus far, currently sit

Indianapolis Colts coach Shane Steichen highlights the unpredictable nature of the NFL, where any team can win on any given day.