Neural activity during the performance of a stereotyped behavioral task is often described as low-dimensional, occupying only a limited region in the space of all firing-rate patterns. This region has ...

The approach is solid, but the choice of learning rules, circuit architecture, and sparsity assumptions is not always sufficiently justified, and the model would benefit from a clearer mechanistic ...

In complex life cycle taxa, the relationship between functional traits and threat status varies across developmental stages, making adult‑based threat predictions insufficient to reflect risks faced ...

The study provides important insight into the development of CD8 T cell virtual memory cells by identifying a dose-sensitive role for Bcl11b. The authors define the developmental stages affected by ...

This study presents valuable findings implicating Xkr and its newly identified binding partners in regulating the exposure of apoptotic signal for phagocytosis, suggesting that Xkr might facilitate ...

This valuable study combines free-flight kinematics, aerodynamic modeling, optogenetics, and connectomics to ask how Drosophila stabilize roll perturbations duri ...

Researchers have created a detailed map of childhood Crohn’s disease before and after treatment which suggests anti-TNF therapy might push the pediatric cell ecosystem towards more resistant disease.

Learn more about eLife assessments Mosquito-borne virus transmission is increasing globally. Due to a lack of effective vaccines or targeted treatments, mitigation relies on reducing human exposure to ...

An in vivo small-molecule drug screen in developing zebrafish larvae identifies dozens of unique chemical modulators capable of reducing atherogenic apolipoprotein B levels.

Plasma cell-free RNA (cfRNA) is a promising source of non-invasive biomarkers, but its clinical translation is hindered by technical challenges and a lack of protocol standardization, which ...

Automated Behavioural Response (ABR) systems, which combine camera traps with automated sound playbacks, offer a solution but have been primarily used on large terrestrial mammals. Here, we ...

Although prenatal alcohol exposure (PAE) has been proposed as an early-life risk factor for Alzheimer’s disease and related dementias (AD/ADRD), the mechanistic underpinnings are underexplored.