Lyophilization (freeze-drying) is commonly utilized to support peptide stability. Removing water from peptide solutions might significantly reduce hydrolysis and deamidation rates. Lyophilized ...

This barricade prevents water from breaking the peptide bonds through a process called hydrolysis. "We provide evidence that that interaction prevents water from attacking the peptide bonds and ...

Proteases are enzymes that catalyse hydrolysis of the peptide and isopeptide bonds that join amino acids within proteins (known as proteolysis). Proteases can also remove protein post ...

Hydrolysis, or peptide bond cleavage via reaction with water, is theorized to be a primary degradation mechanism, particularly in aqueous solutions. Acidic or basic conditions may accelerate this ...

This generally occurs through protease-mediated hydrolysis of peptide bonds, but can also occur through non-enzymatic methods such as by action of mineral acids and heat. Here, Arkinson et al.