In the paper, first author Bradley Clarke and co-authors describe key steps in the mRNA nuclear export pathway and explain how the cellular machinery engages with newly synthesized mRNA.

"Pre-mRNA 3′ end processing is a critical step in mRNA biogenesis, and its misregulation is associated with a variety of diseases, including cancer," said corresponding author Yongsheng Shi, Ph ...

Next Steps for mRNA Vaccines and Therapeutics. ... CureVac has struck a partnership with Tesla to explore whether bioprinters could automate the production process—the costs are likely to be ...

The promise of mRNA technology seemed boundless after the success of the coronavirus vaccines, but Robert F. Kennedy Jr. has singled it out for scrutiny, clouding its prospects.

Ribosomes are tiny molecular machines inside all living cells that build proteins, and ribosome biogenesis is the complex, ...

Within the modern mRNA vaccine production workflow, the mRNA platform has clear advantages, such as enabling short development times and featuring inexpensive manufacturing steps.

3rd mRNA Process Development & Manufacturing Summit, September 17 to 19th 2024. Hear from 30+ expert speakers from the likes of BioNTech, Merck & Co., Moderna, Nutcracker Therapeutics, Pfizer ...

It has become clear that the different steps of pre-mRNA processing, from 5' capping to nuclear export, are tightly co-regulated and coordinated with transcription, translation and mRNA decay.

Obtaining enough synthetic mRNA for clinical use has long been a hurdle in treating conditions like cancer and infectious diseases. Current mRNA production methods involve complex purification steps ...

Join 200+ VPs, Directors and Heads of Process Development, In Vitro Transcription, CMC, MSAT and more as we seek to set manufacturing frameworks, and enable you to support your R and D and analytical ...