PNAS

Apoptosis-inducing factor starts its activity within mitochondria revealed by in situ vibrational probes

The proapoptotic activity of apoptosis-inducing factor (AIF) before its release is explored using label-free Raman spectroscopy and in situ Raman imaging. Electron transfer and interactional details ...
PNAS

PPP1R3G–RIPK1–ZBP1 axis activates early-stage apoptosis and late-stage necroptosis to promote doxorubicin-induced cardiotoxicity

This study identifies Protein Phosphatase 1 Regulatory Subunit 3G (PPP1R3G) as a key driver of doxorubicin-induced cardiotoxicity, acting by removing a protective molecular brake on cell death. We ...
Frontiers

Chronic intermittent hypoxia exacerbates isoproterenol-induced cardiac hypertrophy and apoptosis

Cardiac hypertrophy was induced in mice using ISO, with or without CIH. Echocardiography was performed to assess cardiac functions, while histological analyses were employed to evaluate the ...
News Medical

High-throughput AI quantification of cardiomyocyte hypertrophy in rodent models

This article and associated images are based on a poster originally authored by Katarina Rydén Markinhuhta, Linda Hägerstrand, Margareta Behrendt, Weike Bao, Qing-Dong Wang, Alison Rowles and Pernilla ...
News Medical

Kinetic quantification of apoptosis using Incucyte® live-cell imaging assays

Apoptosis, or programmed cell death, is a tightly regulated biological process necessary for normal tissue maintenance and development. However, aberrations in apoptotic signaling networks are ...
C&EN

High-Throughput Screening Identifies Bisphenol P as a Potent Cardiotoxin, Inducing Cardiotoxicity through Apoptosis and the NF-κB Pathway

Guangdong-Hong Kong Joint Laboratory for Soil and Groundwater Pollution Control, School of Environmental Science and Engineering, Southern University of Science and Technology, Shenzhen 518055, China ...
ahajournals.org

Nrf3-Mediated Mitochondrial Superoxide Promotes Cardiomyocyte Apoptosis and Impairs Cardiac Functions by Suppressing Pitx2

Myocardial infarction (MI) elicits mitochondria reactive oxygen species (ROS) production and cardiomyocyte (CM) apoptosis. Nrf3 (nuclear factor erythroid 2-related factor 3) has an established role in ...