For the first time, researchers have filmed in real time the disassembly of DNA at the atomic scale. This strand separation is the first step in DNA replication. This breakthrough, published ...

The team of researchers from Saudi Arabia identified 15 distinct structural states, demonstrating how adenosine triphosphate (ATP) hydrolysis governs DNA translocation and unwinding. This ...

Water shortens the shelf life of DNA. Biosample integrity is questionable for samples stored in a wet environment owing to the persistent risk of DNA hydrolysis, even at low temperature.

"The helicase uses ATP not to pry DNA apart in one motion, but to cycle through conformational changes that progressively destabilize and separate the strands. ATP burning, or hydrolysis ...

The helicase uses ATP not to pry DNA apart in one motion, but to cycle through conformational changes that progressively destabilize and separate the strands. ATP burning, or hydrolysis ...

Chromatin remodeling plays a vital role in gene regulation, affecting how DNA is accessed. Disruptions in this process can also lead to cancer and other diseases.

On ATP hydrolysis, which releases the DNA, a new heteroduplex is produced if strand exchange has occurred. Otherwise, the filament reforms for additional ATPase cycles of dsDNA binding, homology ...