The San Francisco 49ers certainly have had some bad luck so far this season and are dealing with some high-profile injuries.

San Francisco 49ers star tight end George Kittle missed his second straight practice on Friday as ESPN insider Adam Schefter ...

The Niners will perhaps be without arguably their three most important offensive weapons, sidelined stars Christian McCaffrey ...

Week 3 matchup vs. Rams with key injuries to McCaffrey, Samuel, and Kittle, testing their depth in this crucial NFC West ...

The 49ers’ offense provided one of the toughest challenges for defense due to their ability to line up two of the most unique ...

Herbert injured his right leg in the third quarter of Week 2’s 26-3 win against the Carolina Panthers trying to escape the ...

The San Francisco 49ers will face the Los Angeles Rams on Sunday without wide receiver Deebo Samuel and running back ...

The San Francisco 49ers placed running back Christian McCaffrey on injured reserve on Aug. 14 but have yet to fill his vacant ...

According to Tallysight, a whopping 96% of experts are picking the 49ers to beat the Rams. It’s slightly better when ...

Injuries already are accruing across the NFL, knocking several star players out and forcing teams to turn to backups and ...