Division of Hematology/Oncology, Children’s Hospital of Michigan, Wayne State University, School of Medicine, Detroit, Michigan, USA and reprint requests to: Dr I Warrier, Children’s Hospital of ...

The median life expectancy for cystic fibrosis is now over 30 years, and it is projected that in newborn infants it will become more than 40 years. The identification of the cystic fibrosis gene and ...

We encounter, occasionally, parents who are incapable of making medical decisions on behalf of their incompetent or ...

The hierarchy of evidence in assessing the effectiveness of interventions or treatments is explained, and the gold standard for evaluating the effectiveness of interventions, the randomised controlled ...

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Aim DRC software aims to reduce dosing errors, 1 however, it has been linked to ‘alert fatigue’, a phenomenon which causes prescribers to potentially override alerts despite being clinically relevant.

Objectives Historically diagnoses of Trisomy 13 (T13) and Trisomy 18 (T18) have been associated with a very poor prognosis. Median survival of full T18 is 14days, T13 is 10days and 3-month survival is ...

Objective Leukaemia is the most common cancer of childhood, accounting for a third of cases. In order to assist clinicians in its early detection, we systematically reviewed all existing data on its ...

Anxiety disorders in childhood and adolescence are extremely common and are often associated with lifelong psychiatric disturbance. Consistent with DSM-5 and the extant literature, this review ...

Objectives To describe the range of concurrent cardiac malformations in biliary atresia (BA) while providing a functional framework of risk. Methods Demographic and variables were collected from a ...

Background Over the last few years, there has been increasing attention to the involvement of the central nervous system in Duchenne muscular dystrophy (DMD). The aim of this study was to assess the ...

AIM To identify permanent sequelae after sports injuries in children and adolescents. METHODS In 1985, a prospective register was drawn up of all sports related injuries reported that year by the ...