The non-invasive prenatal test (NIPT) is the last innovation in the field of prenatal diagnosis aimed at helping both practitioners, in the management of pregnancy and its counselling, and future parents in …

Conclusions NIPT is an effective and safe prenatal screening method for trisomies 21, 18, and 13 in the average-risk or general population. Compared with traditional prenatal screening, second-tier NIPT …

Women who do not want fetal aneuploidy information most likely will not undergo NIPT, despite its advantages over other screening tests. However, given its advantages, the decision to have NIPT is …

Non-invasive prenatal testing (NIPT) is a widely adopted maternal blood test that analyses foetal originating DNA to screen for foetal chromosomal conditions, including Down’s syndrome (DS).

This study aims to evaluate the screening performance of both NIPT and NIPT plus, with a particular focus on assessing their effectiveness in combination with ultrasound for comprehensive prenatal …

We analyzed how NIPT was introduced and implemented in the United States (US), Netherlands, and Japan — high-income countries with substantial variation in their introduction and implementation of …

Objective: To assess the performance of a non-invasive prenatal screening test (NIPT) for a panel of dominant single-gene disorders (SGD) with a combined population incidence of 1 in 600.

In this article, we examine the sequencing technologies that provide the framework for non-invasive prenatal testing (NIPT) and review the major North American NIPT clinical validation studies …

Expansion of NIPT beyond the common trisomies is promising, but raises several technical and ethical challenges, which should be addressed. NIPT should always be combined with a skilled ultrasound …

Objective To investigate the uptake of different components of first trimester screening (FTS) and the impact on invasive diagnostic testing (IPT) since the introduction of non-invasive prenatal testing …