At the boundaries of the range of bistability, the steady-state response of the system discontinuously jumps from one state to the other (arrows). The two solid curves represent the stable steady states, which are separated by the unstable steady state (dotted curve).

May 22, 2021 · Bistability exists in networks and we establish that its occurrence depends on the motif structure. We also hypothesize that the structure with larger reversible hysteretic range could be a better drug-target.

Sep 27, 2011 · Rate-balance plots are introduced as a method for determining whether generic one-variable systems exhibit one or several stable steady states. Bifurcation diagrams are presented as a more general method for detecting the presence of bistability in biochemical signaling networks.

Mar 27, 2020 · We scored the extent of bistability by quantifying the range of stimulus that produces a bistable response, the distance between the two responses in the bistable regime, and the area of...

Using a small chemical inhibitor of PAK, we demonstrate that cellular RhoA and Rac1 activation levels respond in a history-dependent, bistable manner to PAK inhibition.

Bistability allows the cell (or area of a cell) to make a discrete digital decision in the face of a range of conflicting external signal gradients and en-sures that the decision made by the cell is fairly robust.

Dec 1, 2019 · Depending on the cooperativity between genes, how the bistability parameter ranges changes in two-dimensional parameter space is observed. In Section 3, the parameter ranges for three different behaviours of the p53 gene network are obtained.

The paper shows that, for a specific 1 − D birth-death process, the parameter ranges for the existence of the deterministic bistability exactly coincide with the parameter ranges for the ...

For reversible bistability, the up-threshold L2 of p is higher than the down-threshold L1 of p. This is hysteresis: a dependence of a state on its current state and past state. Consider a home thermostat. If the temperature is T 18 (e.g., in winter), the heat is on. If the temperature is T ¡ 23 (e.g., in summer), the AC is on.

In this study, we approach the issue of the relationship between bistability and bimodality from a rational viewpoint; i.e., to examine the nature of protein distribution from cells with and without bistability within the framework of population balances.