Speedball, powerball, or over and under[1] is the polydrug mixture of a stimulant with a depressant, usually an opioid. The most well-known mixture used for recreational drug use is that of cocaine and …

Dec 2, 2024 · A speedball is a combination of heroin and cocaine taken intravenously. It can cause harmful effects and requires treatment to manage addiction.

Jan 6, 2026 · A speedball is a dangerous mix of a stimulant (most often cocaine) and a depressant (most often heroin or another opioid). This combination is especially risky because the opposing …

A speedball is a combination of heroin and cocaine that is usually injected, snorted or smoked. The high produced by the stimulant effect of cocaine combined with the depressant effect of heroin is …

Mar 14, 2025 · A speedball is a combination of a stimulant (usually cocaine or methamphetamine) and a CNS depressant (typically an opioid), used simultaneously to produce an intense and dangerous high.

5 days ago · A speedball is the combination of cocaine (stimulant) and heroin (depressant), most commonly injected together, and is one of the most lethal drug combinations ever documented.

Aug 24, 2024 · Speedballing combines the effects of a stimulant and a depressant, leading to a dangerous interplay between the two. Cocaine, a powerful stimulant, increases dopamine levels in …

Nov 7, 2024 · What Is a Speedball? A speedball is a form of polydrug abuse that refers to the combination of stimulant and depressant drugs. This drug combination typically involves …

Oct 19, 2025 · A speedball is a dangerous combination of a stimulant drug, such as cocaine, and a depressant drug, most commonly heroin. The two drugs have opposite effects on the body, which …

Apr 18, 2025 · One of the most notorious forms of polydrug use is called “speedballing.” When someone engages in this type of substance use, they mix a stimulant drug with an opioid. For example, a …