Homepage | Journal of Neurology, Neurosurgery and Psychiatry …
Journal of Neurology, Neurosurgery and Psychiatry (JNNP)'s ambition is to publish the most ground-breaking and cutting-edge research from around the world. Encompassing the entire genre of neurological sciences, our focus is on the common disorders (stroke, multiple sclerosis, Parkinson's disease, epilepsy, peripheral neuropathy, subarachnoid haemorrhage and neuropsychiatry), but with a keen ...
Predictors of outcome in cNORSE: hope for tomorrow
Caring for a patient with a diagnosis of cryptogenic new-onset refractory status epilepticus (cNORSE) is one of the most challenging scenarios facing a clinician: A rare presentation in usually young and previously healthy individuals, lack of evidence and biomarkers to guide treatment, a long duration of illness complicated by status epilepticus (SE) morbidity and a hitherto unpredictable ...
Sodium valproate is associated with cortical thinning of disease ...
Background Juvenile myoclonic epilepsy (JME) is associated with cortical thinning of the motor areas. The relative contribution of antiseizure medication to cortical thickness is unknown. We aimed to investigate how valproate influences the cortical morphology of JME. Methods In this cross-sectional study, individuals with JME with and …
Performance validity test failure in clinical populations—a …
Performance validity tests (PVTs) are widely used in attempts to quantify effort and/or detect negative response bias during neuropsychological testing. However, it can be challenging to interpret the meaning of poor PVT performance in a clinical context. Compensation-seeking populations predominate in the PVT literature. We aimed to establish base rates of PVT failure in clinical populations ...
Idiopathic intracranial hypertension: consensus guidelines on ...
The aim was to capture interdisciplinary expertise from a large group of clinicians, reflecting practice from across the UK and further, to inform subsequent development of a national consensus guidance for optimal management of idiopathic intracranial hypertension (IIH). Methods Between September 2015 and October 2017, a specialist interest group including neurology, neurosurgery ...
Interlocking finger test: a bedside screen for parietal lobe ...
This study sought to determine the utility of an interlocking finger task in screening for parietal lobe dysfunction. The ability of 69 patients to imitate a standardised set of four interlocking finger figures was compared with concurrent performance on formal neurocognitive tests. Poor interlocking finger test scores correlated most highly with …
Recovery patterns and long term prognosis for axonal …
Background: Little is known about the long term prognosis for patients the severe acute motor axonal neuropathy (AMAN) form of Guillain–Barré syndrome (GBS), unlike those with acute inflammatory demyelinating neuropathy (AIDP). Objective: To clarify the long term prognosis for patients with AMAN. Methods: Clinical recovery and outcome in 97 consecutive GBS patients were reviewed. Results ...
Efficacy and safety of adjunctive lacosamide in the treatment of ...
Objective To evaluate efficacy and safety of lacosamide (up to 12 mg/kg/day or 400 mg/day) as adjunctive treatment for uncontrolled primary generalised tonic-clonic seizures (PGTCS) in patients (≥4 years) with idiopathic generalised epilepsy (IGE). Methods Phase 3, double-blind, randomised, placebo-controlled trial (SP0982; [NCT02408523][1]) in patients with IGE and PGTCS taking 1–3 ...
Migraine and risk of stroke | Journal of Neurology, Neurosurgery ...
Migraine and stroke are two common and heterogeneous neurovascular disorders responsible for a significant burden for those affected and a great economic cost for the society. There is growing evidence that migraine increases the overall risk of cerebrovascular diseases. In this review, based on available literature through a PubMed search, we found that ischaemic stroke in …
Mucuna pruriens - Journal of Neurology, Neurosurgery & Psychiatry
Background: The seed powder of the leguminous plant, Mucuna pruriens has long been used in traditional Ayurvedic Indian medicine for diseases including parkinsonism. We have assessed the clinical effects and levodopa (l-dopa) pharmacokinetics following two different doses of mucuna preparation and compared them with standard l-dopa/carbidopa (LD/CD). Methods: Eight Parkinson’s disease ...