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Monoamines, Monoamine Oxidase, and its Inhibitors - The Revisionist
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La hipótesis monoaminérgica de la depresión
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Though lithium is sometimes used as a “treatment” for depression and mania, it is actually an essential nutrient. ⁠ .⁠ Reported deficiency symptoms of this trace element include: Reduced birth weight, depressed fertility, depressed life span, reduced enzyme levels (e.g. monoamine oxidase, glutamate dehydrongenase, etc.).⁠ .⁠ During the early 1970s researchers in Texas discovered that the levels of lithium found in water was inversely associated with the incidence of admissions and re-admissions
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One hypothesis for the mechanism of depression implicates deficits in γ-aminobutyric acid (GABA) and downstream alterations in monoaminergic neurotransmission; this hypothesis is supported by evidence in patients with depression and in patients who have died by suicide. Watch the Quick Take video, then see the trial: https://nej.md/2ku3or7 | The New England Journal of Medicine
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